成永强教授
成永强，男，分析化学博士，教授，博士研究生导师。
研究方向：生化分析与分子诊断。具体是在化学、材料及生物医学等学科发展的基础上，创新分析原理和技术，设计合成新材料，结合核酸扩增技术、纳米粒子探针和高灵敏分子发光检测，发展简便、高效分子诊断和细菌细胞检测及杀伤的新方法新技术。研究工作发表在Angew. Chem. Int. Ed., Anal. Chem., Chem. Commun., ACS Appl. Mater. Interfaces, Analyst 等期刊上。获2012年教育部全国优秀博士学位论文提名；获2012年河北省优秀博士学位论文；获2010年河北省自然科学奖一等奖（2010ZR1002-3）和2017年河北省自然科学奖二等奖（2017ZR2001-2）。
联系方式：E-mail：yqcheng@hbu.edu.cn； yqcheng@126.com
一、主讲课程：仪器分析、仪器分析实验、分子光谱分析
二、研究内容：
1、生物标志物检测及分子诊疗新方法新技术研究。包括基因突变、DNA、RNA及蛋白分析；免疫分析；抗生素、细菌细胞检测及杀伤新方法新技术研究。
2、发光（纳米）探针材料的合成、功能化修饰及其在生化分析中应用研究。
三、代表性论文：
1. Xinrong Yan, Jiangyan Zhang,* Qi Jiang, Dan Jiao, Yongqiang Cheng,* Integration of the Ligase Chain Reaction with the CRISPR-Cas12a System for Homogeneous, Ultrasensitive, and Visual Detection of microRNA, Analytical Chemistry, 2022, 94, 4119−4125.
2. Qi Jiang, Xinrong Yan, Dan Jiao, Jiangyan Zhang,* Yonggang Wu,* Yongqiang Cheng,* Polymyxin B-modified conjugated oligomer nanoparticle for targeted identification and enhanced photodynamic antimicrobial therapy, Chem. Commun., 2021, 57, 11244-11247.
3. 张江艳，严景丽，成永强,* RNA生物标志物体外检测方法研究进展，中国科学：化学，2021，51，1191-1205.
4. Jinying Liu, Jiangyan Zhang,* Meiqi Chen, Dehui Qiu, Xuechong Lv, Qi Jiang, Yongqiang Cheng,* Integration of magnetic separation and real-time ligation chain reaction for detection of uracil-DNA glycosylase, Anal. Bioanal. Chem., 2021, 413, 255-261.
5. Qi Jiang, Fangjie E, Jingxiao Tian, Jiangtao Yang, Jiangyan Zhang,* and Yongqiang Cheng,* Light-Excited Antibiotics for Potentiating Bacterial Killing via Reactive Oxygen Species Generation, ACS Appl. Mater. Interfaces, 2020, 12, 16150-16158.
6. Lingyun Du, Jiangyan Zhang,* Xuange Zhang, Yaru Li, Qi Jiang, Yonggang Wu,* and Yongqiang Cheng*, Multifunctional Oligonucleotide-Functionalized Conjugated Oligomer Nanoparticles for Targeted Cancer Cell Imaging and Therapy, ACS Appl. Bio Mater., 2019, 2, 1340-1347.
7. Jiangyan Zhang, Likun Zhao, Lijuan Dong, Xueyu Nie, Yongqiang Cheng*, Integration of T7 exonuclease-triggered amplification and cationic conjugated polymer biosensing for highly sensitive detection of microRNA, Talanta, 2018, 190, 475-479.
8. Yongqiang Cheng,* Lijuan Dong, Jiangyan Zhang, Yaqing Zhao, and Zhengping Li,* Recent advances in microRNA detection, Analyst, 2018, 143, 1758-1774.
9. Jingxiao Tian, Jiangyan Zhang, Jiangtao Yang, Lingyun Du, Hao Geng, and Yongqiang Cheng,* Conjugated Polymers Act Synergistically with Antibiotics to Combat Bacterial Drug Resistance, ACS Appl. Mater. Interfaces, 2017, 9, 18512-18520.
10. Likun Zhao, Jiangyan Zhang,* Huiming Xu, Hao Geng, and Yongqiang Cheng*, Conjugated Polymers/DNA Hybrid Materials for Protein Inactivation, ACS Appl. Mater. Interfaces, 2016, 8, 22923−22929.
11. Yuanyuan Zhou, Jiangyan Zhang, Likun Zhao, Yingcun Li, Hui Chen, Shengliang Li, and Yongqiang Cheng*, Visual Detection of Multiplex MicroRNAs Using Cationic Conjugated Polymer Materials, ACS Appl. Mater. Interfaces, 2016, 8, 1520-1526.
12. Yingcun Li, Jiangyan Zhang,* Jingjing Zhao, Likun Zhao, Yongqiang Cheng* and Zhengping Li, A simple molecular beacon with duplex-specific nuclease amplification for detection of microRNA, Analyst, 2016, 141, 1071-1076.
13. Zheng Yuan, Yuanyuan Zhou, Shuxin Gao, Yongqiang Cheng*, and Zhengping Li*, Homogeneous and Sensitive Detection of microRNA with Ligase Chain Reaction and Lambda Exonuclease-Assisted Cationic Conjugated Polymer Biosensing, ACS Appl. Mater. Interfaces, 2014, 6, 6181-6185.
14. Yongqiang Cheng*, Jingjing Zhao, Hailian Jia, Zheng Yuan and Zhengping Li*, Ligase chain reaction coupled with rolling circle amplification for high sensitivity detection of single nucleotide polymorphisms, Analyst, 2013, 138, 2958-2963.
15. Yongqiang Cheng*, Qing Du, Liyong Wang, Hailian Jia, and Zhengping Li*, Fluorescently Cationic Conjugated Polymer as an Indicator of Ligase Chain Reaction for Sensitive and Homogeneous Detection of Single Nucleotide Polymorphism, Analytical Chemistry, 2012, 84, 3739-3744.
16. Liyong Wang, Yongqiang Cheng,* Hui Wang, Zhengping Li*, A Homogeneous Fluorescence Sensing Platform with Water-soluble Carbon Nanoparticles for Detection of MicroRNA and Nuclease Activity, Analyst, 2012, 137, 3667-3672.
17. TANG ZhiYuan, CHENG YongQiang*, DU Qing, ZHANG HongXia & LI ZhengPing*, Integration of rolling circle amplification and cationic conjugated polymer for the homogeneous detection of single nucleotide polymorphisms, Chinese Science Bulletin, 2011, 56, 3247-3252.
18. Yongqiang Cheng, Xian Zhang, Zhengping Li, Xiaoxia Jiao, Yucong Wang, and Yali Zhang, Highly Sensitive Determination of microRNA Using Target-Primed and Branched Rolling-Circle Amplification, Angew. Chem. Int. Ed., 2009, 48, 3268-3272.
19. Yongqiang Cheng, Zhengping Li, Baoan Du, and Xian Zhang, Homogeneous and label-free bioluminescence detection of single nucleotide polymorphism with rolling circle amplification, Analyst, 2008, 133, 750-752.
20. Yongqiang Cheng, Zhengping Li, Xian Zhang, Baoan Du, Yongshan Fan, Homogeneous and label-free fluorescence detection of single-nucleotide polymorphism using target-primed branched rolling circle amplification, Anal. Biochem., 2008, 378，123-126.
四、主持科研项目：
1.河北省中央引导地方科技发展项目(236Z3001G)，CRISPR系统介导的超灵敏高通量检测外泌体蛋白标志物研究
2.河北省教育厅重点项目(ZD2021008)，连接酶链式反应结合基因编辑技术均相超灵敏检测核酸标志物研究
3.河北省自然科学基金(B2018201049)，共轭聚合物-抗生素组合协同光动力杀伤耐药菌研究
4.国家自然科学基金(21475031)，DNA水凝胶-阳离子共轭聚合物杂化荧光纳米粒子的制备及其应用于肿瘤细胞成像与治疗研究
5.河北省自然科学基金(B2012201078)，滚环扩增RNA适配体无标记荧光成像原位检测microRNA
6.国家自然科学基金(21075028)，恒温扩增高通量高灵敏度荧光成像检测microRNA 的研究
五、科研获奖：
1.新型生物标志物microRNA的高灵敏度、高选择性分析研究, 河北省自然科学奖二等奖（2017ZR2001-2），2017年度。
2.利用分子发光技术研究高灵敏度分子诊断分析，河北省自然科学奖一等奖（2010ZR1002-3），2010年度。
