院训

李胜辉

一、个人简介

李胜辉, 中国科学院化学研究所博士 (2002-2005)。现为教授,硕士研究生导师。主要从事基于生物活性配体的配位诱导金属有机超分子及具有抗肿瘤活性天然有机小分子类似物的设计、合成及作用机制等研究工作。迄今为止,发表SCI收录论文50余篇;获授权中国发明专利多项,先后主持了河北省自然科学基金-石药集团医药联合研究基金1、河北省自然科学基金面上项目2项。参与多项国家自然科学基金、中国科学院引进国外杰出人才、百人计划及科技部973计划前期研究专项等课题的研究工作。

联系方式:E-mail: lish@hbu.edu.cn

二、主讲课程及研究方向

1.主讲课程: 《有机化学》 《物理有机化学》 《有机合成化学》

2.研究方向: 金属抗肿瘤药物

三、代表性论文

1.Xiaonan Wei, Yaxing Yang, Jiangfeng Ge, Xue Lin, Dandan Liu*, Shuxiang Wang, Jinchao Zhang, Guoqiang Zhou *, Shenghui Li *. Synthesis, characterization, DNA/BSA interactions and in vitro cytotoxicity study of palladium(II) complexes of hispolon derivatives. J. Inorg, Biochem., 2020, 202(1), 110857.

2. Yanci Li, Zhenyu Gu, Can Zhang, Shenghui Li,* Liang Zhang, Guoqiang Zhou*, Shuxiang Wang, Jinchao Zhang. Synthesis, characterization and ROS-mediated antitumor effects of palladium(II) complexes of curcuminoids. Eur. J. Med. Chem. 2018, 144, 662-671.

3. Zhenyu Gu, Yanci Li, Songliang Ma, Shenghui Li,* Guoqiang Zhou*, Shan Ding, Jinchao Zhang, Shuxiang Wang and Chuanqi Zhou. Synthesis, cytotoxic evaluation and DNA binding study of 9-fluoro-6H-indolo[2,3-b]quinoxaline derivatives, RSC Advances, 2017, 7, 41869-41879.

4. Xiaobo Duan, Yingxing Wang, Weipei Feng, Yaxing Yang, Hongyan Li, Shenghui Li*, Xiaobing Yang, Jinchao Zhang*, Shuxiang Wang*, Guoqiang Zhou, Chuanqi Zhou. Design, synthesis and biological evaluation of some novel N-arylpyrazole derivatives bearing the sulfonamide moiety as cytotoxic agents, Res Chem Intermed, 2017, 43(1), 271-281.

5. Hongyan Li, Yingxing Wang, Chao Wang, Shaohan Zhang, Shenghui Li*, Guoqiang Zhou, Shuxiang Wang, Jinchao Zhang*.  Extraction, selenylation modification and antitumor activity of the glucan from Castanea mollissima Blume. Glycoconjugate Journal, 2017, 34(2), 207-217.

6. Huiru Lu, Shenghui Li, Jun Chen, Jing Xia, Jinchao Zhang, Yan Huang, Xiaoxiao Liu, Hai-chen Wu, Yuliang Zhao, Zhifang Chai and Yi Hu. Metal ions modulate the conformation and stability of a G-quadruplex with or without a small-molecule ligand. Metallomics, 2015, 7, 1508-1514.

7. Shenghui Li*, Shengjie Xu, Yonghe Tang, Shan Ding, Jinchao Zhang, Shuxiang Wang, Guoqiang Zhou, Chuanqi Zhou, Xiaoliu Li. Synthesis, anticancer activity and DNA-binding properties of novel 4-pyrazolyl-1,8-naphthalimide derivatives, Bioorg. Med. Chem. Lett., 2014, 24(2), 586-590.

8. Shenghui Li*, Shengjie Xu, Shan Ding, Jinchao Zhang, Shuxiang Wang, Xiaoliu Li.  Chuanqi Zhou, Xiaoliu Li. Synthesis and biological evaluation of some novel N-arylpyrazole derivatives as cytotoxic agents. Res Chem Intermed, 2014, 40(4), 1459-1468.

9. Shenghui Li*, Shan Ding, Shengjie Xu, Jinchao Zhang, Shuxiang Wang, Chuanqi Zhou, Xiaoliu Li. Iodine-catalyzed three-component one-pot synthesis of novel 1,8-dioxo-decahydroacridines derivatives bearing benzene sulfonamide moiety. Res Chem Intermed, 2014, 40(5), 2091-2102.

四、科研项目

1. 靶向G-四链体的11-N-甲基吲哚[2,3-b]喹喔啉衍生物的设计、合成及抗肿瘤活性研究(项目批准号:B2015201213),河北省自然科学基金面上项目(2015-2017年,主持人)

2. 类姜黄素双胍金属配合物的设计、合成及其选择性促氧化抗肿瘤机制研究(项目批准号:B2019201333,河北省自然科学基金面上项目(2019-2021年,主持人)

五、获奖(本人是第一完成人或参与人,河北大学为第一位完成单位获得的政府奖励)

1. 一类新的标志化合物—甲基三环萜烷合成的研究,2002年河北省自然科学三等奖(第五名)

2. 稳定臭氧化物的合成及性质研究,2003年河北省自然科学三等奖(第三名)                  



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