院训

魏超

一、个人简介

魏超,男,中共党员,理学博士,副教授,硕士研究生导师。2016年7月-至今在澳门新葡平台网址8883工作。近年来,主持河北省自然科学基金2项,河北省高等学校科学技术研究项目1项,药物化学与分子诊断教育部重点实验室提升计划1项,以通讯作者在Anal. Chem.Sens. Actuators B Chem.Chem. Commun., Bioorg. Chem.Dyes Pigments, Chem. Asian. J, Org. Biomol. Chem., Spectrochim Acta A.等杂志发表SCI论文30余篇,申请发明专利4件,其中授权3件(已转化1件)

联系方式:weichaohbu@163.com; 13582082879(微信同号)

二、主讲课程及研究方向

1.主讲课程:有机化学,生物有机化学,有机化学实验

2.研究方向:多功能性小分子荧光染料的构筑及应用研究

三、代表性论文

11. Zikang YangXinwei LiTingting SunJiqing BianXiaoyu BuXichuan GeJing SunZugang LiuZhigang XiePeng XiQi Ai*Chao Wei*, and Baoxiang Gao*. Multicolor Tuning of Perylene Diimides Dyes for Targeted Organelle Imaging In Vivo, Anal. Chem., 2024, 96(30), 12331-12340. DOI: 10.1021/acs.analchem.4c01601

10. Yuehua Zhang,‡ Han Zhao,‡ Junshuai Tang, Shiyu Nan, Liqing Lu*, Pingzhu Zhang, Chao Wei*. Lipid droplet-specific near-infrared fluorescent probe for discriminating cancer and normal cells and diagnosing fatty liverBioorg. Chem., 2023, 140, 106800. DOI: 10.1016/j.bioorg.2023.106800

9. Junshuai Tang, Pingzhu Zhang*, Zimeng Li, Yuehua Zhang, Hua Chen, Xiaoliu Li, Chao Wei*. A Simple Ratiometric Fluorescent Probe for Two-Photon Imaging of Carbon Monoxide in Living Cells and Zebrafish, Bioorg. Chem., 2023, 135, 106489.  DOI: 10.1016/j.bioorg.2023.106489

8. Han Zhao, Mei Wang*, Zimeng Li, Yajing Meng, Zhenbo Guo, Pingzhu Zhang, Xiaoliu Li, Chao Wei*. Rational design of metal-free fluorescent probe for tracking CO-releasing molecule-3 in vitro and in vivoSens. Actuators B Chem., 2023, 377, 133059. DOI: 10.1016/j.snb.2022.133059

7. Zimeng Li,‡ Jingshuo Gao,‡ Zhenbo Guo, Han Zhao, Liyan Liu, Mei Wang, Pingzhu Zhang, Guofeng Chen*, Xiaoliu Li, Chao Wei*. Monitoring the Fluctuation of H2S in Insulin-Resistant HepG2 Cells and Diabetic Mice with a Dual-Locked NIR Fluorescent ProbeSens. Actuators B Chem., 2022, 353, 131141. DOI: 10.1016/j.snb.2021.131141

6. Zimeng Li,‡ Xu Jia,‡ Pingzhu Zhang*, Zhenbo Guo, Han Zhao, Xiaoliu Li*, Chao Wei*. A hepatocyte-specific fluorescent probe for imaging endogenous carbon monoxide release in vitro and in vivoSens. Actuators B Chem., 2021, 344, 130177. DOI: 10.1016/j.snb.2021.130177

5. Xu Jia, Chao Wei*, Zimeng Li, Liyan Liu, Mei Wang, Pingzhu Zhang, Xiaoliu Li*Selective Imaging of HClO in the Liver Tissue in vivo Using a Near-infrared Hepatocyte-specific Fluorescent ProbeChem. Asian. J., 2021, 16, 1967-1972. DOI: 10.1002/asia.202100476

4. Meng Yao,‡ Xu Jia,‡ Mei Wang*, Xin Li, Xiaoli Wang, Hongqiang Qu*, Xiaoliu Li, Chao Wei*. Visualizing hydrogen sulfide in HepG2 cells exposed to OGD/R and in the liver of zebrafish with a hepatocyte-targeting fluorescent probe, Dyes Pigments, 2021, 185, 109151. DOI: 10.1016/j.dyepig.2021.109151

3. Jingshuo Gao,‡ Xu Jia,‡ Zhenbo Guo, Shuhan Yang, Lingyu Wei, Pingzhu Zhang, Chao Wei*, Guofeng Chen*, Xiaoliu Li. A two-photon benzocoumarin-NBD dyad for highly selective and sensitive ratiometric detection of H2S in biological samples, Dyes Pigments, 2021, 185, 108906. DOI: 10.1016/j.dyepig.2020.108906

2. Zhenbo Guo, Mei Wang*, Xueyan Li, Xu Jia, Xiaoli Wang, Pingzhu Zhang, Chao Wei*, Xiaoliu Li. A hepatocyte-targeting fluorescent probe for imaging isoniazid-induced hydrazine in HepG2 cells and zebrafish, Chem. Commun., 2020, 56, 14183-14186. DOI: 10.1039/D0CC05330A

1. Chen Ma, Chao Wei*, Xueyan Li, Xueyang Zheng, Bin Chen, Mei Wang, Pingzhu Zhang, Xiaoliu Li*. A mitochondria-targeted dual-reactable fluorescent probe for fast detection of H2S in living cells, Dyes Pigments, 2019, 162, 624-631. DOI: 10.1016/j.dyepig.2018.10.072


四、科研项目

1. 糖基化修饰近红外荧光/光声探针用于炎症性肠病的成像检测研究,河北省自然科学面上项目,项目批准号:B2022201016, 2022/01-2024/12,主持。

2. 苯硼酸双光子荧光探针用于肿瘤细胞表面Lewis寡糖特异性识别及生物成像应用研究,河北省自然科学青年基金,项目批准号:B2018201234,2018/01-2020/12,主持。

3. 基于多重淬灭效应的高灵敏比率计量型过氧化氢荧光探针的构建及生物应用,河北省高等学校科学技术研究项目,项目批准号:QN2017014,2017/01-2019/12,主持。

4. 双光子比例计量型一氧化碳荧光探针的设计合成及应用,药物化学与分子诊断教育部重点实验室提升计划,项目批准号:ts2020001, 2020/01-2022/12,主持。

五、授权专利

1. 四苯乙烯硼酸基吡啶盐、制备方法与应用及检测果糖的试剂、方法  专利号:ZL202010342626.6

2. GalNAc修饰的美兰衍生物、其制备方法与应用及肝靶向荧光探针、HClO的检测方法  专利号:ZL2020105885488.8

六、获奖情况

1. 河北大学第十届青年教师课堂教学大赛二等奖

2. 保定市第十届大中专院校青年教师讲课比赛理科组二等奖

3. 2024年河北大学课程思政教学竞赛三等奖

4. 第一届河北省大学生化学实验创新设计竞赛三等奖(优秀指导教师)

5. 第四届河北省大学生化学实验创新设计竞赛二等奖(优秀指导教师)


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