严景丽

一、个人简介

严景丽, 中国科学院化学研究所(2010-2013)，北京大学博士后(2013-2015)。现为副教授，硕士研究生导师。迄今为止，发表SCI收录论文12篇；获授权中国发明专利1项，先后主持了国家自然科学基金、博士后面上基金、公安部开放课题，共计3项课题。

联系方式：E-mail:  yanjinglichem@hbu.edu.cn        

                               yanjinglichem@163.com

二、主讲课程及研究方向

1.主讲课程：基础化学分析实验、基础分析仪器实验

2.研究方向：DNA和microRNA的检测分析，DNA甲基化及RNA甲基化的分析研究，体液鉴定分析方法的建立。

三、代表性论文

1. Wenyue Zhang, Wenhui Hao, Xuetao Liu, Xiru Sun, Jingli Yan* and Yucong Wang*, Visual detection of miRNAs using enzyme-free amplification reactions and ratiometric fluorescent probes. Talanta, 2020, 219, 121332.

2. Zhenhao Zhang, Jingli Yan* and Zhengping Li*. Peroxotungstate oxidation- mediated two-phase amplification system (POM-TPAS) for bisulfite-free quantification of locus-specific 5-hydroxymethylcytosine. Chemical Communications, 2020, 56, 3111-3114.

3. Zhenhao Zhang, Xiao Shan, Pengbo Zhang, Weiliang Liu, Jingli Yan* and Zhengping Li*. Highly sensitive quantification of site-specific 5-hydroxymethylcytosine at single-base resolution by HpaII-mediated ligation PCR. Organic & Biomolecular Chemistry, 2019,17, 9849-9853.

4. Weiliang Liu, Jingli Yan*, Zhenhao Zhang, Hongru Pian, Chenghui Liu and Zhengping Li*. Identification of a selective DNA ligase for accurate recognition and ultrasensitive quantification of N6-methyladenosine in RNA at one-nucleotide resolution. Chemical Science, 2018, 9, 3354-3359.

5. Hui Wen, Hui Wang, Honghong Wang, Jingli Yan*, Hui Tian and Zhengping Li*. Ultrasensitive detection of site-specific DNA methylation by loop-mediated isothermal amplification. Analytical Methods, 2016, 8, 5372-5377.

6. Yue Huang^†, Jingli Yan^†, Qi Li, Jiafei Li, Shouzhe Gong, Hu Zhou, Jianhua Gan, Hualiang Jiang, Gui-Fang Jia*, Cheng Luo*, and Cai-Guang Yang*, Meclofenamic acid selectively inhibits FTO demethylation of m6A over ALKBH5, Nucleic Acids Research, 2015, 43, 373–384.

四、获奖

新型生物标志物microRNA的高灵敏度、高选择性的分析,2017年河北省自然科学奖二等奖（第五名）。