一、个人简介
张金超, 二级教授,博士生导师。男,汉族,1969年7月出生,河北省武强县人,浙江大学博士,北京大学博士后,香港城市大学高级访问学者。河北省自然基金委创新群体项目负责人、河北省自然科学基金杰出青年基金获得者、河北省青年科技奖获得者、河北省新世纪“三三三人才工程”第一层次人选、河北省高校百名优秀创新人才、河北省政府特殊津贴专家;现为中国生物物理学会纳米生物学分会副会长,中国化学会理事。现任新型药物制剂与辅料全国重点实验室副主任,药物化学与分子诊断教育部重点实验室常务副主任。
长期从事纳米生物材料的制备及生物医学领域应用的研究工作,迄今为止以第一作者(通讯作者)在Adv. Mater.、Nano Lett.、ACS Nano、Biomaterials等国际知名期刊上发表SCI论文200余篇,获授权中国发明专利20余项,先后主持了国家“重大新药创制”科技重大专项、国家重点研发课题、国家自然科学基金、教育部科学技术研究重点项目、河北省自然基金创新研究群体项目、河北省自然基金杰出青年基金、河北省自然基金重点项目、河北省应用基础研究计划重点基础研究项目等30余项课题。作为第一完成人,先后获河北省自然科学一等奖(2019年),河北省自然科学二等奖(2014年度, 2022年度)和河北省科技进步三等奖(2017年)。作为第三完成人,获北京市自然科学一等奖一项。
联系方式:E-mail: jczhang6970@163.com
二、主讲课程及研究方向
1.主讲课程:有机化学,生物无机化学,化学生物学
2.研究方向:纳米医学与分子诊疗。
三、代表性论文
1.Shutao Gao, Pengli Zheng, Zhenhua Li*, Xiaochen Feng, Weixiao Yan, Shizhu Chen, Weisheng Guo, Dandan Liu, Xinjian Yang, Shuxiang Wang, Xing-Jie Liang*, Jinchao Zhang*. Biomimetic O2-Evolving metal-organic framework nanoplatform for highly efficient photodynamic therapy against hypoxic tumor. Biomaterials, 2018, 178, 83-94.
2.Hongjuan Li#, Weixiao Yan#, Xiaomin Su, Haotong Peng, Xinjian Yang, Zhenhua Li, Jinchao Zhang*, Dandan Liu*. Nucleus-targeted nano delivery system eradicates cancer stem cells by combined thermotherapy and hypoxia-activated chemotherapy. Biomaterials, 2019, 200, 1-14.
3.Chunyue Gao, Yi Jin*, Guang Jia, Xiaoming Suo, Huifang Liu, Dandan Liu, Xingjian Yang, Kun Ge, Xing-jie Liang, Shuxiang Wang*, Jinchao Zhang*. Y2O3 nanoparticles caused bone tissue damage by breaking the intracellular phosphate balance in bone marrow stromal cells. ACSNano, 2019, 13, 313-323.
4.Wentong Sun, Kun Ge*, Yan Jin, Yu Han, Haisong Zhang, Guoqiang Zhou, Xinjian Yang, Dandan Liu, Huifang Liu, Xing-Jie Liang, Jinchao Zhang*. Bone-targeted nanoplatform combining zoledronate and photothermal therapy to treat breast cancer bone metastasis. ACS Nano, 2019, 13, 7556–7567.
5.Shutao Gao, Yan Jin, Kun Ge, Zhenhua Li,* Huifang Liu, Xinyue Dai, Yinghua Zhang,Shizhu Chen, Xingjie Liang,* and Jinchao Zhang*. Self-supply of O2 and H2O2 by a nanocatalytic medicine to enhance combined chemo/chemodynamic therapy. Adv. Sci. 2019, 1902137.
6.Xiaowei Ma, # Jiadong Sun, # Lin Zhong, Yufei Wang, Qianqian Huang, Xiaoli Liu, Shubin Jin,* Jinchao Zhang,* and Xing-Jie Liang*. Evaluation of turning-sized gold nanoparticles on cellular adhesion by Golgi disruption in vitro and in vivo. Nano Lett. 2019, 19, 8476-8487
7.Miao Fan#, Yu Han#, Shutao Gao, Hongyu Yan, Lingzhi Cao, Zhenhua Li, Xing-Jie Liang*, Jinchao Zhang*. Ultrasmall gold nanoparticles in cancer diagnosis and therapy. Theranostics, 2020, 10(11), 4944–4957
8. Yinghua Zhang, Huifang Liu, Xinyue Dai, Hang Li, Xiaohan Zhou, Shizhu Chen, Jinchao Zhang*, Xing-Jie Liang, and Zhenhua Li*. Cyanobacteria-based near-infrared light-excited self-supplying oxygen system for enhanced photodynamic therapy of hypoxic tumors. Nano Res. 2021, 14(3): 667–673.
9.Pengli Zheng#, Miao Fan#, Huifang Liu, Yinghua Zhang, Xinyue Dai, Hang Li, Xiaohan Zhou, Shiqi Hu, Xinjian Yang, Yi Jin, Na Yu, Shutao Guo, Jinchao Zhang,* Xing-Jie Liang, Ke Cheng,* Zhenhua Li*. Self-Propelled and Near-Infrared-Phototaxic Photosynthetic Bacteria as Photothermal Agents for Hypoxia-Targeted Cancer Therapy. ACS Nano, 2021, 15, 1100−1110.
10. Hao Wang#, Yi Jin#, Yanli Tan, Han Zhu, Wendi Huo, Pei Niu, Zhenhua Li, Jinchao Zhang*, Xing-jie Liang, Xinjian Yang*. Photo-responsive hydrogel facilitates nutrition deprivation by an ambidextrous approach for preventing cancer recurrence and metastasis. Biomaterials, 2021, 275, 120992.
11.Erman Zhaoa, Huifang Liu*, Yaru Jiaa, Tingshan Xiaoa, Jiaxin Li, Guoqiang Zhou, June Wang, Xiaohan Zhou, Xing-Jie Liang, Jinchao Zhang*, Zhenhua Li*. Engineering a photosynthetic bacteria-incorporated hydrogel for infected wound healing. Acta Biomaterialia, 2022, 140: 302–313
12.Miao Fan, Huifang Liu, Hongyu Yan, Ruijun Che, Yi Jin, Xinjian Yang, Xiaohan Zhou, Hua Yang, Kun Ge, Xing-Jie Liang, Jinchao Zhang*, Zhenhua Li*.A CAR T-inspiring platform based on antibody-engineered exosomes from antigen-feeding dendritic cells for precise solid tumor therapy. Biomaterials, 2022, 282, 121424.
13.Wendi Huo, Xinjian Yang *, Bei Wang, Lingzhi Cao, Ziyuan Fang, Zhenhua Li, Huifang Liu, Xing-jie Liang, Jinchao Zhang*, Yi Jin*. Biomineralized hydrogel DC vaccine for cancer immunotherapy: A boosting strategy via improving immunogenicity and reversing immune-inhibitory microenvironment. Biomaterials, 2022, 2882, 121722.
14.Miao Fan, Hang Li, Deliang Shen, Zhaoshuo Wang, Huifang Liu, Dashuai Zhu, ZhenzhenWang, Lanya Li, KristenD. Popowski, Caiwen Ou, Kaihan Zhang, Jinchao Zhang,* Ke Cheng,* and Zhenhua Li*. Decoy exosomes offer protection against chemotherapy-induced toxicity. Adv. Sci., 2022, 9(32): 2203505.
15.Lili Ma, Yao Wang, Xiuguang Wang, Qingjia Zhu, Yunli Wang, Luwei Li, Hong-Bo Cheng*, Jinchao Zhang*, Xing-Jie Liang*.Transition metal complex-based smart AIEgens explored for cancer diagnosis and theranostics. Coordination Chemistry Reviews, 2022, 473, 214822.
16.Yutao Yang, Yan Zhang, Ming Ma, Hongmei Liu, Kun Ge, Chunfang Zhang, Ming Jin, Dandan Liu, Shuxiang Wang,* Caixia Yin,* and Jinchao Zhang*.Synergistic modulation by halogens and pyridine crossing the blood-brain barrier for in situ visualization of thiol flux in the epileptic brain. Anal. Chem. 2022, 94, 14443-14452
17.Yutao Yang, Keyan Zhou, Ming Ma, Hongmei Liu, Ming Jin, Caixia Yin*, Shuxiang Wang *, Jinchao Zhang*. Thiol “click” chromene mediated cascade reaction forming coumarin for in-situ imaging of thiol flux in drug-induced liver injury. Chemical Engineering Journal, 2023, 452, 139020.
Yi-Feng Wang, Yaxin Zhou, Jiabei Sun, Xiaotong Wang, Yaru Jia , Kun Ge, Yan Yan , Kenneth A. Dawson, Shutao Guo*, Jinchao Zhang*, and Xing-Jie Liang*. The Yin and Yang of protein corona on the delivery journey of nanoparticles. Nano Res., 2023, 16(1): 715-734
19.Kai Wu, Wei Zhang, Hao Chen, Jie Wu , Xiaotong Wang , Xinjian Yang , Xing-Jie Liang , Jinchao Zhang*, Dandan Liu*. An iron oxyhydroxide-based nanosystem sensitizes ferroptosis by a“Three-Pronged” strategy in breast cancer stem cells. Acta Biomaterialia, 2023, 160, 281–296.
四、科研项目
1.人工稀土纳米材料对骨髓基质细胞成骨分化和成脂分化的调控及分子机制(项目批准号:21271059), 国家自然科学基金项目( 2013-2016年, 主持人)
2.基于pH响应、可将接介孔二氧化硅/磷灰石复合纳米颗粒的制备及其在抗肿瘤方面的应用(项目批准号:31470961), 国家自然科学基金项目(2014-2017年, 主持人)
3.基于多级MOF的纳米级联催化体系的构建及其用于肿瘤治疗的研究(批准号:31971304), 国家自然科学基金面上项目(2020-2023年,主持人)
4.靶向肿瘤干细胞的多功能磁性二氧化硅纳米载药体系的构建及其抗肿瘤作用研究(项目批准号:B2017201226),河北省自然科学基金重点项目(2017-2019年, 主持人)
5.双亲性可离子化分子的构建优化及其组装规律(项目批准号:2021YFA1201001),国家重点研发计划课题(2021-2026年,主持人)
6.抗肿瘤纳米药物(项目批准号:2021201038),河北省自然科学基金创新研究群体项目(2021-2023年,主持人)
五、获奖
1. 骨质疏松症防治的基础与应用研究,2017年河北省科技进步三等奖(第一名)
2.新型贵金属类抗肿瘤配合物的设计、合成及机制研究; 2014年河北省自然科学二等奖(第一名)
3. 新型铂类抗肿瘤药物的设计、合成及其作用机制,2019年河北省自然科学一等奖(第一名)
4. 纳米材料亚细胞效应的理化适配基础研究,2021年北京市自然科学一等奖(第三名)
5.人工合成无机纳米材料调控骨代谢的作用及机制,2022年河北省自然科学二等奖(第一名)